GSK3: a multifaceted kinase in Wnt signaling
نویسندگان
چکیده
منابع مشابه
Wnt Signaling: Multivesicular Bodies Hold GSK3 Captive
Two key events in Wnt signal transduction, receptor endocytosis and inactivation of Glycogen Synthase Kinase 3 (GSK3), remain incompletely understood. Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a new framework for understanding Wnt signaling.
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2010
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2009.10.002